[PDF][PDF] Cancer cachexia: mediators, signaling, and metabolic pathways

KCH Fearon, DJ Glass, DC Guttridge - Cell metabolism, 2012 - cell.com
Cancer cachexia is characterized by a significant reduction in body weight resulting
predominantly from loss of adipose tissue and skeletal muscle. Cachexia causes reduced cancer …

Cancer-associated cachexia

VE Baracos, L Martin, M Korc, DC Guttridge… - Nature reviews Disease …, 2018 - nature.com
Cancer-associated cachexia is a disorder characterized by loss of body weight with specific
losses of skeletal muscle and adipose tissue. Cachexia is driven by a variable combination …

Inflammation induced loss of skeletal muscle

P Londhe, DC Guttridge - Bone, 2015 - Elsevier
Inflammation is an important contributor to the pathology of diseases implicated in skeletal
muscle dysfunction. A number of diseases and disorders including inflammatory myopathies …

NF-κB controls cell growth and differentiation through transcriptional regulation of cyclin D1

DC Guttridge, C Albanese, JY Reuther… - … and cellular biology, 1999 - Am Soc Microbiol
… phenylmethylsulfonyl fluoride and 1 μg of poly(dI-dC)-poly(dI-dC) in a volume of 12 μl for 10
… of phenylmethylsulfonyl fluoride and poly(dI-dC)-poly(dI-dC). The antibodies used for this …

NF-κB-Induced Loss of MyoD Messenger RNA: Possible Role in Muscle Decay and Cachexia

DC Guttridge, MW Mayo, LV Madrid, CY Wang… - Science, 2000 - science.org
MyoD regulates skeletal muscle differentiation (SMD) and is essential for repair of damaged
tissue. The transcription factor nuclear factor kappa B (NF-κB) is activated by the cytokine …

NF-κB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis

CY Wang, DC Guttridge, MW Mayo… - Molecular and cellular …, 1999 - Taylor & Francis
… Five-microgram aliquots nuclear extracts of cells were preincubated with 1 μg of poly(dI-dc)
in binding buffer (10 mM Tris [pH 7.7], 50 mM NaCl, 20% glycerol, 1 mM dithiothreitol [DTT], …

Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-κB

LV Madrid, CY Wang, DC Guttridge… - … and cellular biology, 2000 - Am Soc Microbiol
It is well established that cell survival signals stimulated by growth factors, cytokines, and
oncoproteins are initiated by phosphoinositide 3-kinase (PI3K)-and Akt-dependent signal …

[PDF][PDF] NF-κB–YY1–miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma

…, SJ Qualman, DS Chandler, CM Croce, DC Guttridge - Cancer cell, 2008 - cell.com
Guttridge1,3,* 1Human Cancer Genetics Program, Department of Molecular Virology, …
We thank members of the Guttridge laboratory for their support and insight throughout the …

[PDF][PDF] Microglia induce motor neuron death via the classical NF-κB pathway in amyotrophic lateral sclerosis

…, KD Foust, JP Godbout, PG Popovich, DC Guttridge… - Neuron, 2014 - cell.com
Neuroinflammation is one of the most striking hallmarks of amyotrophic lateral sclerosis (ALS).
Nuclear factor-kappa B (NF-κB), a master regulator of inflammation, is upregulated in …

[HTML][HTML] Cancer cachexia is regulated by selective targeting of skeletal muscle gene products

…, PJ Reiser, S Swoap, DC Guttridge - The Journal of …, 2004 - Am Soc Clin Investig
… The authors wish to thank members of the Guttridge laboratory and S. Liyanarachchi for their
experimental advice and helpful discussions throughout the course of this study. This work …