TRAIL signalling: decisions between life and death
C Falschlehner, CH Emmerich, B Gerlach… - The international journal …, 2007 - Elsevier
… The apoptosome is formed upon release of cytochrome c from the mitochondria, a process
that is ultimately controlled by the interaction of members of the Bcl-2 family, and association …
that is ultimately controlled by the interaction of members of the Bcl-2 family, and association …
[HTML][HTML] Improving target assessment in biomedical research: the GOT-IT recommendations
CH Emmerich, LM Gamboa, MCJ Hofmann… - Nature reviews Drug …, 2021 - nature.com
… of activity for certain drugs can be limited if the target is not conserved across related bacteria
or viruses, which has recently been shown for antivirals developed to treat hepatitis C virus …
or viruses, which has recently been shown for antivirals developed to treat hepatitis C virus …
[HTML][HTML] Optimising methods for the preservation, capture and identification of ubiquitin chains and ubiquitylated proteins by immunoblotting
CH Emmerich, P Cohen - Biochemical and biophysical research …, 2015 - Elsevier
… These linkages are formed by the covalent attachment of the C-terminus of ubiquitin to the
ε-amino groups of any of the seven lysine (K) residues in ubiquitin (K6, K11, K27, K29, K33, …
ε-amino groups of any of the seven lysine (K) residues in ubiquitin (K6, K11, K27, K29, K33, …
Linear ubiquitination prevents inflammation and regulates immune signalling
B Gerlach, SM Cordier, AC Schmukle, CH Emmerich… - Nature, 2011 - nature.com
Members of the tumour necrosis factor (TNF) receptor superfamily have important functions
in immunity and inflammation. Recently linear ubiquitin chains assembled by a complex …
in immunity and inflammation. Recently linear ubiquitin chains assembled by a complex …
[PDF][PDF] Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction
TL Haas, CH Emmerich, B Gerlach, AC Schmukle… - Molecular cell, 2009 - cell.com
TNF is a key inflammatory cytokine. Using a modified tandem affinity purification approach,
we identified HOIL-1 and HOIP as functional components of the native TNF-R1 signaling …
we identified HOIL-1 and HOIP as functional components of the native TNF-R1 signaling …
Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains
CH Emmerich, A Ordureau… - Proceedings of the …, 2013 - National Acad Sciences
Polyubiquitin (pUb) chains formed between the C terminus of ubiquitin and lysine 63 (K63)
or methionine 1 (M1) of another ubiquitin have been implicated in the activation of the …
or methionine 1 (M1) of another ubiquitin have been implicated in the activation of the …
The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system
S Strickson, DG Campbell, CH Emmerich… - Biochemical …, 2013 - portlandpress.com
… BAY 11-7082 prevents ubiquitin conjugation to Ubc13 and UbcH7 by forming a covalent
adduct with their reactive cysteine residues via Michael addition at the C 3 atom of BAY 11-7082…
adduct with their reactive cysteine residues via Michael addition at the C 3 atom of BAY 11-7082…
Heritage of Religious Liberty
AM Adams, CJ Emmerich - U. Pa. L. Rev., 1988 - HeinOnline
Recognizing that an examination of history can be hazardous as well as fruitful, this Article
will address the historical meaning of a constitutional provision that represents one of …
will address the historical meaning of a constitutional provision that represents one of …
Refined structure of concanavalin A complexed with methyl α-D-mannopyranoside at 2.0 Å resolution and comparison with the saccharide-free structure
JH Naismith, C Emmerich, J Habash… - … Section D: Biological …, 1994 - scripts.iucr.org
The three-dimensional structure of the complex between methyl α-d-mannopyranoside and
concanavalin A has been refined at 2.0 Å resolution. Diffraction data were recorded from a …
concanavalin A has been refined at 2.0 Å resolution. Diffraction data were recorded from a …
[HTML][HTML] Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation
VA McGuire, T Ruiz-Zorrilla Diez, CH Emmerich… - Scientific reports, 2016 - nature.com
Dimethyl fumarate (DMF) possesses anti-inflammatory properties and is approved for the
treatment of psoriasis and multiple sclerosis. While clinically effective, its molecular target has …
treatment of psoriasis and multiple sclerosis. While clinically effective, its molecular target has …