Play is of vital importance for the healthy development of children. From a developmental
perspective, play offers ample physical, emotional, cognitive, and social benefits. It allows …

Meconium ileus at birth, distal intestinal obstruction syndrome (DIOS), and constipation are
an interrelated group of intestinal obstruction syndromes with a variable severity of …

Cystic fibrosis is the most prevalent inherited disease caused by a defect in the cystic fibrosis
transmembrane conductance regulator (CFTR) gene. The impaired electrolyte homeostasis …

Single murine and human intestinal stem cells can be expanded in culture over long time
periods as genetically and phenotypically stable epithelial organoids. Increased cAMP levels …

We recently established conditions allowing for long-term expansion of epithelial organoids
from intestine, recapitulating essential features of the in vivo tissue architecture. Here we …

Organoids are self‐organizing 3D structures grown from stem cells that recapitulate essential
aspects of organ structure and function. Here, we describe a method to establish long‐term…

Background Combination treatment with the cystic fibrosis transmembrane conductance
regulator (CFTR) modulators tezacaftor (VX-661) and ivacaftor (VX-770) was designed to target …

… ), EM Nieuwhof-Stoppelenburg, EC van der Wiel (Department of Pediatric Pulmonology, …
Arets HGM, Brackel HJL, van der Ent CK, Applicability of interrupter resistance … van der Ent …

Background Preterm birth, low birth weight, and infant catch-up growth seem associated
with an increased risk of respiratory diseases in later life, but individual studies showed …

… van der Ent … van der Ent1,15,* … to this work, especially EM Nieuwhof-Stoppelenburg, EC
Kooij-van der Wiel, and JC Escher (Department of Pediatric Pulmonology, Erasmus Medical …