User profiles for C. E. Chalfant

Charles Chalfant

Verified email at virginia.edu
Cited by 10789

Ceramide in apoptosis: an overview and current perspectives

BJ Pettus, CE Chalfant, YA Hannun - … (BBA)-Molecular and Cell Biology of …, 2002 - Elsevier
Recent years have witnessed significant advances in the understanding of the role of ceramide
in apoptosis. This review summarizes these recent findings and discusses insights from …

Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling

CE Chalfant, S Spiegel - Journal of cell science, 2005 - journals.biologists.com
The phosphorylated sphingolipid metabolites sphingosine 1-phosphate (S1P) and ceramide
1-phosphate (C1P) have emerged as potent bioactive agents. Recent studies have begun …

[HTML][HTML] Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2

…, J Freiberg, P Roddy, YA Hannun, CE Chalfant - Journal of Biological …, 2004 - ASBMB
Recently, we demonstrated that ceramide kinase, and its product, ceramide 1-phosphate (Cer-1-P),
were mediators of arachidonic acid released in cells in response to interleukin-1β …

The sphingosine kinase 1/sphingosine‐1‐phosphate pathway mediates COX‐2 induction and PGE2 production in response to TNF‐α

…, KR Johnson, J Morrow, CE Chalfant… - The FASEB …, 2003 - Wiley Online Library
In this study we addressed the role of sphingolipid metabolism in the inflammatory response.
In a L929 fibroblast model, tumor necrosis factor‐α (TNF) induced prostaglandin E 2 (PGE …

[HTML][HTML] De Novo Ceramide Regulates the Alternative Splicing of Caspase 9 and Bcl-x in A549 Lung Adenocarcinoma Cells: DEPENDENCE ON PROTEIN …

CE Chalfant, K Rathman, RL Pinkerman… - Journal of Biological …, 2002 - ASBMB
Previous studies have demonstrated that several splice variants are derived from both the
caspase 9 and Bcl-x genes in which the Bcl-x splice variant, Bcl-x(L) and the caspase 9 splice …

The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x

…, T Achsel, A Massiello, CE Chalfant… - The Journal of cell …, 2007 - rupress.org
The RNA-binding protein Sam68 is involved in apoptosis, but its cellular mRNA targets and
its mechanism of action remain unknown. We demonstrate that Sam68 binds the mRNA for …

[HTML][HTML] Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A: activation is stereospecific and regulated by phosphatidic acid

CE Chalfant, K Kishikawa, MC Mumby… - Journal of Biological …, 1999 - ASBMB
The search for potential targets for ceramide action led to the identification of ceramide-activated
protein phosphatases, which include protein phosphatase-2A (PP2A) and protein …

[HTML][HTML] Ceramide kinase mediates cytokine-and calcium ionophore-induced arachidonic acid release

…, S Spiegel, P Roddy, YA Hannun, CE Chalfant - Journal of Biological …, 2003 - ASBMB
Despite the importance of prostaglandins, little is known about the regulation of prostanoid
synthesis proximal to the activation of cytosolic phospholipase A 2 , the initial rate-limiting step…

Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids

…, L Malinina, EH Hinchcliffe, CE Chalfant… - Nature, 2013 - nature.com
Phosphorylated sphingolipids ceramide-1-phosphate (C1P) and sphingosine-1-phosphate (S1P)
have emerged as key regulators of cell growth, survival, migration and inflammation 1 , …

Metabolic gene remodeling and mitochondrial dysfunction in failing right ventricular hypertrophy secondary to pulmonary arterial hypertension

…, DS Wijesinghe, CE Chalfant… - Circulation: Heart …, 2013 - Am Heart Assoc
Background— Right ventricular (RV) dysfunction (RVD) is the most frequent cause of death
in patients with pulmonary arterial hypertension. Although abnormal energy substrate use …