Covering: up to 2017 The innate immune system employs a broad array of antimicrobial
peptides (AMPs) to attack invading microorganisms. While most AMPs act by permeabilizing the …

Expression of the Escherichia coli tryptophanase operon depends on ribosome stalling during
translation of the upstream TnaC leader peptide, a process for which interactions between …

The increasing prevalence of antibiotic-resistant pathogens reinforces the need for structures
of antibiotic-ribosome complexes that are accurate enough to enable the rational design of …

We examined differences between blinded and retrospective reviews of screening mammograms
obtained before a mammogram that resulted in the diagnosis of an impalpable breast …

During peptide-bond formation on the ribosome, the α-amine of an aminoacyl-tRNA attacks
the ester carbonyl carbon of a peptidyl-tRNA to yield a peptide lengthened by one amino acid…

The increasing prevalence of multidrug-resistant pathogenic bacteria is making current
antibiotics obsolete. Proline-rich antimicrobial peptides (PrAMPs) display potent activity against …

We review here signalling complexes that we have defined using X-ray analysis in our
laboratory. They include growth factors and their receptors: nerve growth factor (NGF) and its …

Sensing small molecules is crucial for microorganisms to adapt their genetic programs to
changes in their environment. Arrest peptides encoded by short regulatory open reading …

Ribosomal stalling is used to regulate gene expression and can occur in a species-specific
manner. Stalling during translation of the MifM leader peptide regulates expression of the …

Macrolides and ketolides comprise a family of clinically important antibiotics that inhibit
protein synthesis by binding within the exit tunnel of the bacterial ribosome. While these …