Compelling evidence indicates that two autosomal recessive Parkinson's disease genes,
PINK1 (PARK6) and Parkin (PARK2), cooperate to mediate the autophagic clearance of …

While mitochondrial dysfunction is emerging as key in Parkinson's disease (PD), a central
question remains whether mitochondria are actual disease drivers and whether boosting …

The Parkinson’s disease factors PINK1 and parkin are strongly implicated in stress-induced
mitophagy in vitro, but little is known about their impact on basal mitophagy in vivo. We …

GBA gene mutations are the greatest cause of Parkinson disease (PD). GBA encodes the
lysosomal enzyme glucocerebrosidase (GCase) but the mechanisms by which loss of GCase …

Hexanucleotide repeat expansions in the C9ORF72 gene are the commonest known genetic
cause of amyotrophic lateral sclerosis and frontotemporal dementia. Expression of repeat …

Cancer is the leading cause of death after liver transplantation (LT). This multicenter case–control
nested study aimed to evaluate the effect of maintenance immunosuppression on post‐…

Wallerian degeneration of physically injured axons involves a well-defined molecular pathway
linking loss of axonal survival factor NMNAT2 to activation of pro-degenerative protein …

Genetic analysis of Parkinson disease (PD) has identified several genes whose mutation
causes inherited parkinsonism, as well as risk loci for sporadic PD. PTEN-induced kinase 1 (…

Mitophagy removes defective mitochondria via lysosomal elimination. Increased mitophagy
coincides with metabolic reprogramming, yet it remains unknown whether mitophagy is a …

Respiratory complex I powers ATP synthesis by oxidative phosphorylation, exploiting the
energy from NADH oxidation by ubiquinone to drive protons across an energy-transducing …