This review presents the precise syntheses of a variety of new chain-end- and in-chain-multi-functionalized
polymers, regular and asymmetric star-branched polymers, star-linear block …

Hematopoietic stem cells (HSCs) are defined by their ability both to self-renew and to give
rise to fresh blood cells throughout the lifetime of an animal. The failure of HSCs to self-renew …

Recent evidence indicates that osteoblasts are crucial components of the particular
microenvironments, or niches, for hematopoietic stem cells (HSCs) in adult bone marrow (BM). Stem …

Chronic myeloid leukaemia (CML) is caused by a defined genetic abnormality that
generates BCR-ABL, a constitutively active tyrosine kinase 1 . It is widely believed that BCR-ABL …

Chk2 is a protein kinase that is activated in response to DNA damage and may regulate cell
cycle arrest. We generated Chk2-deficient mouse cells by gene targeting. Chk2 −/− …

The quiescent state is thought to be an indispensable property for the maintenance of
hematopoietic stem cells (HSCs). Interaction of HSCs with their particular microenvironments, …

Hematopoietic stem cells (HSCs) undergo self-renewing cell divisions and maintain blood
production for their lifetime 1 . Appropriate control of HSC self-renewal is crucial for the …

The ‘ataxia telangiectasia mutated’ (Atm) gene maintains genomic stability by activating a
key cell-cycle checkpoint in response to DNA damage, telomeric instability or oxidative stress …

Hematopoietic stem cells (HSCs) are maintained in an undifferentiated quiescent state within
a bone marrow niche. Here we show that Foxo3a, a forkhead transcription factor that acts …

Hematopoietic stem cells (HSCs) are sustained in a specific microenvironment known as
the stem cell niche. Mammalian HSCs are kept quiescent in the endosteal niche, a hypoxic …