[PDF][PDF] A systematic p53 mutation library links differential functional impact to cancer mutation pattern and evolutionary conservation
…, G Goldfeld, M Lotan-Pompan, O Tarcic, A Gershoni… - Molecular cell, 2018 - cell.com
The TP53 gene is frequently mutated in human cancer. Research has focused predominantly
on six major "hotspot" codons, which account for only ∼30% of cancer-associated p53 …
on six major "hotspot" codons, which account for only ∼30% of cancer-associated p53 …
The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation
Y Aylon, A Gershoni, R Rotkopf, IE Biton… - Genes & …, 2016 - genesdev.cshlp.org
The Hippo signaling pathway is a major regulator of organ size. In the liver, Hippo pathway
deregulation promotes hyperplasia and hepatocellular carcinoma primarily through …
deregulation promotes hyperplasia and hepatocellular carcinoma primarily through …
[HTML][HTML] Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patients
…, A Avioz, O Iancu, G Mallel, A Gershoni… - Nature …, 2022 - nature.com
The TP53 gene is mutated in approximately 60% of all colorectal cancer (CRC) cases. Over
20% of all TP53-mutated CRC tumors carry missense mutations at position R175 or R273. …
20% of all TP53-mutated CRC tumors carry missense mutations at position R175 or R273. …
Cross-talk between mutant p53 and p62/SQSTM1 augments cancer cell migration by promoting the degradation of cell adhesion proteins
…, M Shreberk-Shaked, A Gershoni… - Proceedings of the …, 2022 - National Acad Sciences
Missense mutations in the p53 tumor suppressor abound in human cancer. Common (“hotspot”)
mutations endow mutant p53 (mutp53) proteins with oncogenic gain of function (GOF), …
mutations endow mutant p53 (mutp53) proteins with oncogenic gain of function (GOF), …
Patients wearing face masks during intravitreal injections may be at a higher risk of endophthalmitis
A Hadayer, A Zahavi, E Livny, O Gal-Or, A Gershoni… - Retina, 2020 - journals.lww.com
Purpose: To investigate the safety of face masks worn by patients during intravitreal injections.
Methods: A prospective, qualitative, interventional study performed in a tertiary university …
Methods: A prospective, qualitative, interventional study performed in a tertiary university …
TAZ facilitates breast tumor growth by promoting an immune‐suppressive tumor microenvironment
A Gershoni, O Hassin, NB Nataraj, S Baruch… - Molecular …, 2023 - Wiley Online Library
The core Hippo pathway module consists of a tumour‐suppressive kinase cascade that
inhibits the transcriptional coactivators Yes‐associated protein (YAP) and WW domain‐…
inhibits the transcriptional coactivators Yes‐associated protein (YAP) and WW domain‐…
[HTML][HTML] High agreement between Barrett Universal II calculations with and without utilization of optional biometry parameters
Y Vega, A Gershoni, A Achiron, R Tuuminen… - Journal of clinical …, 2021 - mdpi.com
Purpose: To examine the contribution of anterior chamber depth (ACD), lens thickness (LT),
and white-to-white (WTW) measurements to intraocular lens (IOL) power calculations using …
and white-to-white (WTW) measurements to intraocular lens (IOL) power calculations using …
LATS1 and LATS2 suppress breast cancer progression by maintaining cell identity and metabolic state
…, I Rivkin, I Schmitt, D Bakaev, A Gershoni… - Life science …, 2018 - life-science-alliance.org
Deregulated activity of LArge Tumor Suppressor (LATS) tumor suppressors has broad
implications on cellular and tissue homeostasis. We examined the consequences of down-…
implications on cellular and tissue homeostasis. We examined the consequences of down-…
[HTML][HTML] Research productivity across different ophthalmic subspecialties in the United States
A Gershoni, I Vainer, O Reitblat, FB Mimouni… - BMC Health Services …, 2019 - Springer
Background The purpose of this study was to compare the h-index, and subsequently the
research productivity, among different ophthalmic subspecialties in the United States. Methods …
research productivity, among different ophthalmic subspecialties in the United States. Methods …
[HTML][HTML] Thickness measurements taken with the spectralis OCT increase with decreasing signal strength
Background Optical coherence tomography (OCT) is used worldwide by clinicians to evaluate
macular and retinal nerve fiber layer (RNFL) characteristics. It is frequently utilized to …
macular and retinal nerve fiber layer (RNFL) characteristics. It is frequently utilized to …