Many oncogenic insults deregulate RNA splicing, often leading to hypersensitivity of tumors
to spliceosome-targeted therapies (STTs). However, the mechanisms by which STTs …

Cancer proteogenomics promises new insights into cancer biology and treatment efficacy by
integrating genomics, transcriptomics and protein profiling including modifications by mass …

In quantitative mass spectrometry, the method by which peptides are grouped into proteins
can have dramatic effects on downstream analyses. Here we describe gpGrouper, an …

Protein synthesis is frequently dysregulated in cancer and selective inhibition of mRNA
translation represents an attractive cancer therapy. Here, we show that therapeutically targeting …

Combined methylmalonic acidemia and homocystinuria (cblC) is the most common inborn
error of intracellular cobalamin metabolism and due to mutations in Methylmalonic Aciduria …

Although systemic chemotherapy remains the standard of care for TNBC, even combination
chemotherapy is often ineffective. The identification of biomarkers for differential …

A Clinical Proteomic Tumor Analysis Consortium (CPTAC) proteogenomic analysis
prioritized dihydropyrimidinase-like-3 (DPYSL3) as a multilevel (RNA/protein/phosphoprotein) …

The cardiac fibroblast interacts with an extracellular matrix (ECM), enabling myofibroblast
maturation via a process called mechanosensing. Although in the aging male heart, ECM is …

Background Proton pump inhibitors (PPIs) are widely prescribed drugs for the treatment of
gastroesophageal reflux disease (GERD). Several meta-analysis studies have reported …

Ligand binding to the cell surface receptors initiates signaling cascades that are commonly
transduced through a protein–protein interaction (PPI) network to activate a plethora of …