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| Status |
Public on Oct 10, 2017 |
| Title |
Quantitative Transcriptome Analysis of T cells stimulated with STING ligands |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
STING plays a key role in detecting cytosolic DNA and induces type I interferon responses for host defense against pathogens. Although T cells highly express STING, its physiological role remains unknown. In this study, we show that costimulation of T cells via TCR and STING ligand induce type I IFN responses like innate immune cells.
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| Overall design |
Naïve CD4+ T cells were stimulated with anti-CD3/28 in the presence or absence of STING ligand and analyzed the transcriptome using Illumina HiSeq1500.
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| Contributor(s) |
Imanishi T, Saito T |
| Citation(s) |
30683688 |
| Submission date |
Oct 09, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Takayuki Imanishi |
| E-mail(s) |
takayuki.imanishi@riken.jp
|
| Organization name |
RIKEN Center for Integrative Medical Sciences (IMS)
|
| Street address |
1-7-22 Suehiro-cho, Tsurumi-ku
|
| City |
Yokohama |
| ZIP/Postal code |
230-0045 |
| Country |
Japan |
| |
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| Platforms (1) |
| GPL18480 |
Illumina HiSeq 1500 (Mus musculus) |
|
| Samples (10)
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| Relations |
| BioProject |
PRJNA413658 |
| SRA |
SRP119595 |
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