Abstract
The outer membranes of Gram-negative bacteria constitute a semi-permeable barrier, as indicated by the corresponding alterations in outer membrane permeability and in antibiotic susceptibility resulting from mutation or polycation action. Restricted outer membrane permeability works in synergy with co-determinant resistance mechanisms, such as the periplasmic enzyme beta-lactamase or active efflux mechanisms, bringing about antibiotic resistance.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Anti-Bacterial Agents / pharmacokinetics*
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Cations / pharmacology
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Cell Membrane / chemistry
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Cell Membrane Permeability / drug effects*
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Cell Membrane Permeability / genetics
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Cell Membrane Permeability / physiology
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Drug Resistance, Microbial / genetics
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Drug Resistance, Microbial / physiology
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Gram-Negative Bacteria / cytology*
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Gram-Negative Bacteria / genetics
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Gram-Negative Bacteria / physiology
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Molecular Structure
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Mutation
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beta-Lactamases / metabolism
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beta-Lactams
Substances
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Anti-Bacterial Agents
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Cations
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beta-Lactams
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beta-Lactamases