Licensing of DNA replication, cancer, pluripotency and differentiation: an interlinked world?

S Champeris Tsaniras; N Kanellakis; I E Symeonidou; P Nikolopoulou; Z Lygerou; S Taraviras

doi:10.1016/j.semcdb.2014.03.013

Licensing of DNA replication, cancer, pluripotency and differentiation: an interlinked world?

Semin Cell Dev Biol. 2014 Jun:30:174-80. doi: 10.1016/j.semcdb.2014.03.013. Epub 2014 Mar 15.

Authors

S Champeris Tsaniras¹, N Kanellakis², I E Symeonidou³, P Nikolopoulou⁴, Z Lygerou⁵, S Taraviras⁶

Affiliations

¹ Department of Physiology, Medical School, University of Patras, Rio, 26504 Patras, Greece. Electronic address: schamperis@upatras.gr.
² Department of Physiology, Medical School, University of Patras, Rio, 26504 Patras, Greece. Electronic address: kanellakis@upatras.gr.
³ Department of Biology, Medical School, University of Patras, Rio, 26504 Patras, Greece. Electronic address: eleannasym@googlemail.com.
⁴ Department of Physiology, Medical School, University of Patras, Rio, 26504 Patras, Greece. Electronic address: pinelopinik@hotmail.com.
⁵ Department of Biology, Medical School, University of Patras, Rio, 26504 Patras, Greece. Electronic address: lygerou@med.upatras.gr.
⁶ Department of Physiology, Medical School, University of Patras, Rio, 26504 Patras, Greece. Electronic address: taraviras@med.upatras.gr.

PMID: 24641889
DOI: 10.1016/j.semcdb.2014.03.013

Abstract

Recent findings provide evidence for a functional interplay between DNA replication and the seemingly distinct areas of cancer, development and pluripotency. Protein complexes participating in DNA replication origin licensing are now known to have roles in development, while their deregulation can lead to cancer. Moreover, transcription factors implicated in the maintenance of or reversal to the pluripotent state have links to the pre-replicative machinery. Several studies have shown that overexpression of these factors is associated to cancer.

Keywords: Cancer; DNA replication; Development; Licensing; Origin specification; Pluripotency.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Differentiation
DNA Replication*
Epigenesis, Genetic
Gene Expression Regulation, Neoplastic
Humans
Neoplasms / genetics*
Neoplasms / pathology
Neoplastic Stem Cells / physiology
Pluripotent Stem Cells / physiology