Abstract
Synaptic loss is currently established as the best neurobiological correlate of the cognitive deficits of Alzheimer's disease (AD) [Ann. Neurol. 27 (1990) 457; Ann. Neurol. 30 (1991) 572]. We provide evidence that still living neurons lose synapses in AD, in addition to the synapse loss due to death of neurons. We also provide evidence indicating that in addition to loss of synapses, synaptic function is also affected in AD by decrements in transcript species related to synaptic vesicle trafficking.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Alzheimer Disease / pathology*
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Alzheimer Disease / physiopathology*
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Animals
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Gene Expression Profiling
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Humans
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Nerve Degeneration / pathology*
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Nerve Degeneration / physiopathology*
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Nerve Tissue Proteins / genetics
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Nerve Tissue Proteins / metabolism
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Neurofibrillary Tangles / metabolism
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Neurofibrillary Tangles / pathology
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Protein Transport / physiology
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Synapses / metabolism
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Synapses / pathology*
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Synapses / ultrastructure
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Synaptic Vesicles / metabolism
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Synaptic Vesicles / pathology
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Synaptic Vesicles / ultrastructure