Targeting monocyte recruitment in CNS autoimmune disease

Clin Immunol. 2002 May;103(2):125-31. doi: 10.1006/clim.2001.5167.

Abstract

Monocytes and macrophages play a pathogenic role in a number of autoimmune inflammatory diseases. Recent studies in experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis, have identified a critical chemokine-mediated mechanism of monocyte homing to the central nervous system (CNS). Here, we summarize the current findings in EAE, develop a rationale for targeting the chemokine axis in order to treat CNS inflammatory disease, and review currently available molecule-specific therapeutics that inhibit monocyte trafficking to the CNS.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / etiology
  • Autoimmune Diseases / immunology*
  • Autoimmune Diseases / therapy
  • Central Nervous System Diseases / etiology
  • Central Nervous System Diseases / immunology*
  • Central Nervous System Diseases / therapy
  • Chemokine CCL2 / metabolism
  • Chemokines / metabolism
  • Disease Models, Animal
  • Encephalomyelitis, Autoimmune, Experimental / etiology
  • Encephalomyelitis, Autoimmune, Experimental / immunology
  • Humans
  • Mice
  • Mice, Knockout
  • Models, Immunological
  • Monocytes / immunology*
  • Multiple Sclerosis / etiology
  • Multiple Sclerosis / immunology
  • Receptors, CCR2
  • Receptors, Chemokine / metabolism

Substances

  • CCR2 protein, human
  • Ccr2 protein, mouse
  • Chemokine CCL2
  • Chemokines
  • Receptors, CCR2
  • Receptors, Chemokine