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Delivering nonidentical twins

Nature Structural & Molecular Biology volume 21, pages 649–651 (2014)Cite this article

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Two sibling DNA polymerases synthesize most of the eukaryotic nuclear genome. A new study provides insights into the distinct protein interactions that deliver these replicases for asymmetric leading- and lagging-strand replication and reveals possible cross-talk between DNA replication and other cellular processes.

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Figure 1: Comparison of DNA polymerases δ and ε.
Figure 2: The eukaryotic replication fork.

References

  1. Johansson, E. & Dixon, N. Cold Spring Harb. Perspect. Biol. 5, a012799 (2013).

    Article  Google Scholar 

  2. Georgescu, R.E. et al. Nat. Struct. Mol. Biol. doi:10.1038/nsmb.2851 (6 July 2014).

  3. Bell, S.D. & Botchan, M.R. Cold Spring Harb. Perspect. Biol. 5, a012807 (2013).

    Article  Google Scholar 

  4. Chilkova, O. et al. Nucleic Acids Res. 35, 6588–6597 (2007).

    Article  CAS  Google Scholar 

  5. Gambus, A. et al. EMBO J. 28, 2992–3004 (2009).

    Article  CAS  Google Scholar 

  6. Kesti, T., Flick, K., Keranen, S., Syvaoja, J.E. & Wittenberg, C. Mol. Cell 3, 679–685 (1999).

    Article  CAS  Google Scholar 

  7. Dua, R., Levy, D.L. & Campbell, J.L. J. Biol. Chem. 274, 22283–22288 (1999).

    Article  CAS  Google Scholar 

  8. O'Donnell, M., Langston, L. & Stillman, B. Cold Spring Harb. Perspect. Biol. 5, a010108 (2013).

    Article  Google Scholar 

  9. Jiricny, J. Cold Spring Harb. Perspect. Biol. 5, a012633 (2013).

    Article  Google Scholar 

  10. Williams, J.S. & Kunkel, T.A. DNA Repair (Amst) 19, 27–37 (2014).

    Article  CAS  Google Scholar 

  11. MacAlpine, D.M. & Almouzni, G. Cold Spring Harb. Perspect. Biol. 5, a010207 (2013).

    Article  Google Scholar 

  12. Jin, Y.H. et al. Mol. Cell Biol. 25, 461–471 (2005).

    Article  CAS  Google Scholar 

  13. Nick McElhinny, S.A., Pavlov, Y.I. & Kunkel, T.A. Cell Cycle 5, 958–962 (2006).

    Article  CAS  Google Scholar 

  14. Pluciennik, A. et al. Proc. Natl. Acad. Sci. USA 107, 16066–16071 (2010).

    Article  CAS  Google Scholar 

  15. Shibahara, K. & Stillman, B. Cell 96, 575–585 (1999).

    Article  CAS  Google Scholar 

  16. Smith, D.J. & Whitehouse, I. Nature 483, 434–438 (2012).

    Article  CAS  Google Scholar 

  17. Lujan, S.A. et al. PLoS Genet. 8, e1003016 (2012).

    Article  CAS  Google Scholar 

  18. Albertson, T.M. et al. Proc. Natl. Acad. Sci. USA 106, 17101–17104 (2009).

    Article  CAS  Google Scholar 

  19. Yeeles, J.T., Poli, J., Marians, K.J. & Pasero, P. Cold Spring Harb. Perspect. Biol. 5, a012815 (2013).

    Article  Google Scholar 

  20. Ghosal, G. & Chen, J. Transl. Cancer Res. 2, 107–129 (2013).

    CAS  PubMed  PubMed Central  Google Scholar 

  21. Pacek, M. & Walter, J.C. EMBO J. 23, 3667–3676 (2004).

    Article  CAS  Google Scholar 

  22. Heller, R.C. et al. Cell 146, 80–91 (2011).

    Article  CAS  Google Scholar 

  23. Garcia-Diaz, M. & Kunkel, T.A. Trends Biochem. Sci. 31, 206–214 (2006).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

Research in the authors' laboratories is supported by Project Z01 ES065070 from the Division of Intramural Research of the US National Institutes of Health (National Institute of Environmental Health Sciences) to T.A.K. and by grant GM032431 from the US National Institutes of Health to P.M.B.

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Authors and Affiliations

  1. Thomas A. Kunkel is at the Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA.,

    Thomas A Kunkel

  2. Peter M. Burgers is at the Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri, USA.,

    Peter M Burgers

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  1. Thomas A Kunkel
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  2. Peter M Burgers
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Correspondence to Thomas A Kunkel.

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Kunkel, T., Burgers, P. Delivering nonidentical twins. Nat Struct Mol Biol 21, 649–651 (2014). https://doi.org/10.1038/nsmb.2852

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