Molecular Cell
Volume 49, Issue 4, 21 February 2013, Pages 680-691
ArticleRoles of R2D2, a Cytoplasmic D2 Body Component, in the Endogenous siRNA Pathway in Drosophila
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Highlights
► Dcr-2 and R2D2 are necessary for the formation of cytoplasmic foci, D2 bodies ► R2D2 localizes Dcr-2 and endo-siRNAs to D2 bodies to control endo-siRNA sorting ► Ago2, but not Ago1, is localized to D2 bodies ► Ago2-specific loading of exo-siRNAs and guide siRNA selection are R2D2 independent
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These authors contributed equally to this work
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Present address: School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
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Present address: Center for Transdisciplinary Research, Niigata University, Niigata 950-2181, Japan
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Present address: Graduate School of Science, The University of Tokyo, Tokyo 113-0032, Japan
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