Immunity
Volume 32, Issue 5, 28 May 2010, Pages 692-702
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Article
Toll-like Receptor 2 Signaling in CD4+ T Lymphocytes Promotes T Helper 17 Responses and Regulates the Pathogenesis of Autoimmune Disease

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Summary

Toll-like receptors (TLRs) have previously been shown to play critical roles in the activation of innate immunity. Here, we describe that T cell expression of TLR2 regulates T helper 17 (Th17) cell responses. Stimulation with TLR2 agonists promoted Th17 differentiation in vitro and led to more robust proliferation and Th17 cytokine production. Using the experimental autoimmune encephalomyelitis (EAE) model, we found that TLR2 regulated Th17 cell-mediated autoimmunity in vivo and that loss of TLR2 in CD4+ T cells dramatically ameliorated EAE. This study thus reveals a critical role of a TLR in the direct regulation of adaptive immune response and pathogenesis of autoimmune diseases.

Highlights

► TLR2 expression is upregulated following Th17 cell differentiation ► TLR2 signaling enhances Th17 differentiation ► TLR2 expression in T cells is required for EAE induction

MOLIMMUNO
CELLIMMUNO

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Present address: Department of Melanoma Medical Oncology, M.D. Anderson Cancer Center, Houston, TX 77054, USA