Cell
Volume 146, Issue 6, 16 September 2011, Pages 931-941
ArticleSelective Bypass of a Lagging Strand Roadblock by the Eukaryotic Replicative DNA Helicase
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Graphical Abstract
Highlights
► Replicative helicase CMG can bypass a lagging strand but not a leading strand roadblock ► This suggests that native CMG translocates along ssDNA in the 3′ to 5′ direction ► MCM2-7 reconfigures from a dsDNA to a ssDNA binding mode during replication initiation
Cited by (0)
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Present address: Tecan Group Ltd., 8708 Männedorf, Switzerland
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Present address: Helsinn Therapeutics (U.S.) Inc., Bridgewater, NJ 08807, USA
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Present address: The Zernike Institute for Advanced Materials, University of Groningen, 9747 AG Groningen, The Netherlands
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These authors contributed equally to this work
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