Cell
Volume 146, Issue 3, 5 August 2011, Pages 372-383
ArticleSpo11-Accessory Proteins Link Double-Strand Break Sites to the Chromosome Axis in Early Meiotic Recombination
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Graphical Abstract
Highlights
► Pre-DSB recombinosome components Rec114, Mer2, and Mei4 bind to chromosome axis sites ► Binding requires S phase Cdk and axial element components and is modulated by cohesion ► Loss of axis site binding correlates with loss of DSBs in budding yeast ► The DSB machinery may link hotspots to axis sites prior to DSB formation
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Present address: Institut de Génétique et de Biologie Moléculaire et Cellulaire, 1 rue Laurent Fries, 67404 Illkirch Cedex, Strasbourg, France
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Present address: EUCODIS Bioscience, Viehmarktgasse 2A, A-1030 Vienna, Austria
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