Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
Volume 1834, Issue 10, October 2013, Pages 2187-2194
ReviewCollagen recognition and transmembrane signalling by discoidin domain receptors☆
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open access
Highlights
► DDR1 and DDR2 are receptor tyrosine kinases that are activated by collagen. ► DDR activation by collagen is slow and sustained. ► The principles of collagen recognition are understood from structural studies. ► The mechanism of transmembrane signalling is currently not understood. ► Possible activation mechanisms are discussed.
Abbreviations
DDR
discoidin domain receptor
DS
discoidin
ECM
extracellular matrix
JM
juxtamembrane
mAb
monoclonal antibody
RTK
receptor tyrosine kinase
TM
transmembrane
Keywords
Receptor tyrosine kinase
Collagen
X-ray crystallography
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This article is part of a Special Issue entitled: Emerging recognition and activation mechanisms of receptor tyrosine kinases.
Copyright © 2012 Elsevier B.V.