Elsevier

Advanced Drug Delivery Reviews

Volume 86, 23 June 2015, Pages 17-26
Advanced Drug Delivery Reviews

Prediction of drug–ABC-transporter interaction — Recent advances and future challenges

https://doi.org/10.1016/j.addr.2015.03.001Get rights and content
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open access

Abstract

With the discovery of P-glycoprotein (P-gp), it became evident that ABC-transporters play a vital role in bioavailability and toxicity of drugs. They prevent intracellular accumulation of toxic compounds, which renders them a major defense mechanism against xenotoxic compounds. Their expression in cells of all major barriers (intestine, blood–brain barrier, blood–placenta barrier) as well as in metabolic organs (liver, kidney) also explains their influence on the ADMET properties of drugs and drug candidates. Thus, in silico models for the prediction of the probability of a compound to interact with P-gp or analogous transporters are of high value in the early phase of the drug discovery process. Within this review, we highlight recent developments in the area, with a special focus on the molecular basis of drug–transporter interaction. In addition, with the recent availability of X-ray structures of several ABC-transporters, also structure-based design methods have been applied and will be addressed.

Keywords

ABC transporters
Computational models
Bioassays
Machine learning
Pharmacophore modeling
Transport inhibition

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This review is part of the Advanced Drug Delivery Reviews theme issue on “In silico ADMET predictions in pharmaceutical research”.