Characterization of the Human Colon Carcinoma Cell Line (Caco-2) as a Model System for Intestinal Epithelial Permeability+,++
References (55)
- et al.
Intestinal metabolism of glutamine and glutamate from the lumen as compared to glutamine from blood
Arch Biochem Biophys
(1975) - et al.
Intestinal drug absorption and metabolism I: comparison of methods and models to study physiological factors of in vitro and in vivo intestinal absorption
J Pharm Sci
(1970) - et al.
Purification of the human intestinal brush border membrane
Biochim Biophys Acta
(1973) - et al.
Turnover of brush-border glycoproteins in human intestinal absorptive cells: do lysosomes have a regulatory function
Cell Biol Int Rep
(1984) - et al.
Epithelial differentiation in the fetal rat colon. I. Plasma membrane phosphatase activities
Dev Biol
(1983) - et al.
Isolation of basolateral membranes from columnar cells of the proximal colon of the guinea pig
Biochim Biophys Acta
(1983) - et al.
Macromolecular transport in the fetal rat intestine
Gastroenterology
(1985) - et al.
A novel cell line (Caco-2) for the study of intestinal lipoprotein synthesis
J Biol Chem
(1987) - et al.
Polarized secretion of newly synthesized lipoproteins by the Caco-2 human intestinal cell line
J Lipid Res
(1987) - et al.
Development of vasoactive intestinal peptide-responsive adenylate cyclase during enterocyte differentiation of Caco-2 cells in culture
J Biol Chem
(1987)
In vitro drug absorption models. I. Brush border membrane vesicles, isolated mucosal cells and everted intestinal rings: characterization and salicylate accumulation
Pharm Res
(1985)
Separation and use of enterocytes
Epithelioid cell cultures from rat small intestine. Characterization by morphologic and immunologic criteria
J Cell Biol
(1979)
Behaviour of isolated rat intestinal cells maintained in suspension or monolayer cultures
Biol Cell
(1978)
Enterocytic differentiation of cultured human colon cancer cells by replacement of glucose by galactose in the medium
Biol Cell
(1982)
Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture
Biol Cell
(1983)
Classification of human colorectal adenocarcinoma cell lines
Cancer Res
(1976)
Establishment and description of a new line
In Vitro
(1976)
Improvements in epoxy resin embedding methods
J Biophys Biochem Cytol
(1961)
The use of lead citrate at high pH as an opaque stain in electron microscopy
J Cell Biol
(1963)
Ultrastructural localization of several phosphatases with cerium
J Histochem Cytochem
(1983)
Improved localization of intracellular sites of phosphatases using cerium and cell permeabilization
J Histochem Cytochem
(1985)
Migration of neutrophils across monolayers of cultured microvascular endothelial cells: an in vitro model of leukocyte extravasation
J Cell Sci
(1987)
A formaldehyde-glutaraldehyde fixative of high osmolality for use in electron microscopy
J Cell Biol
(1965)
Imidazole increases the sensitivity of the cytochemical reaction for peroxidase with diaminobenzidine at a neutral pH
J Histochem Cytochem
(1982)
Cell surface polarity in epithelia
Ann Rev Cell Biol
(1985)
Enterocytic differentiation and glucose utilization in the human colon tumor cell line Caco-2: modulation by forskolin
J Cell Physiol
(1985)
Cited by (0)
- +
This study was supported by a grant from The Upjohn Co., Kalamazoo, Michigan.
- ++
The authors thank Dr. David P. Thompson for transepithelial electrical resistance measurements and Dr. Moo J. Cho for helpful criticism.
Copyright © 1989 American Gastroenterological Association. Published by Elsevier Inc. All rights reserved.