Elsevier

Neuroscience Letters

Volume 129, Issue 2, 19 August 1991, Pages 221-224
Neuroscience Letters

Sequential expression of JUN B, JUN D and FOS B proteins in rat spinal neurons: Cascade of transcriptional operations during nociception

https://doi.org/10.1016/0304-3940(91)90466-7Get rights and content

Abstract

Expression of the immediate-early gene encoded proteins JUN B, JUN D and FOS B was investigated by immunocytochemistry in rat L5 spinal cord up to 24 h following stimulation of hind limb somatosensory nociceptors by noxious heat or injection of formalin. In both experimental protocols, JUN B, which did not show basal expression, reached maximum expression after 2 h and thereafter slowly decreased. In contrast, the expression of JUN D, which was present before stimulation in many spinal neurons, was increased after 4 h, reached its maximum after 8 h and thereafter remained elevated. FOS B which was absent under basal conditions reached its maximum between 4 h and 8 h and thereafter declined but was still present after 24 h. All immunoreactivities were restricted to the ipsilateral dorsal horn except JUN D which was also induced in the contralateral side after 8 h. The results are discussed in respect to their meaning for transcriptional operations of JUN and FOS proteins.

References (22)

  • A. Barzilai et al.

    5-HT modulates protein synthesis and the expression of specific proteins during long-term facilitation in Aplysia sensory neurons

    Neuron

    (1990)
  • Cited by (0)

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