Spatial expression of the Drosophila segment polarity gene armadillo is posttranscriptionally regulated by wingless

doi:10.1016/0092-8674(90)90451-J

Cell

Volume 63, Issue 3, 2 November 1990, Pages 549-560

https://doi.org/10.1016/0092-8674(90)90451-J Get rights and content

Abstract

armadillo (arm) is one of a group of Drosophila segment polarity genes that are required for normal patterning within the embryonic segment. Although arm RNA is uniformly distributed in embryos, arm protein accumulates at higher levels in regions that contain wingless, another segment polarity gene which encodes a secreted protein that regulates patterning via cell-cell communication. These local increases in arm protein require wingless activity, and mutations that alter wingless distribution produce corresponding changes in the arm protein pattern. These results suggest that wingless regulates accumulation of arm protein by a posttranscriptional mechanism. Two other segment polarity genes, porcupine and dishevelled, are required for this effect. We also show that arm protein is closely associated with the plasma membrane in virtually all cell types and often colocalizes with F-actin.

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^★: Present address: Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112.

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Cell

ArticleSpatial expression of the Drosophila segment polarity gene armadillo is posttranscriptionally regulated by wingless

Abstract

Dev. Biol.

Cell

J. Biol. Chem.

Cell

Dev. Biol.

Cell

Dev. Biol.

Dev. Biol.

Cell

Cell

Cell

Cell

J. Theor. Biol.

Molecular cloning of sequences from wingless, a segment polarity gene in Drosophila: the spatial distribution of a transcript in embryos

EMBO J.

Localization of transcripts from the wingless gene in whole Drosophila embryos

Development

The nuclear localization signal of Xenopus laevis nucleoplasmin

EMBO J.

The embryonic development of Drosophila melanogaster

Production and purification of polyclonal antibodies for the foreign segment of β-galactosidase fusion proteins

Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis

Nature

Homology of a yeast actin binding protein to signal transduction proteins and myosin

Nature

Localized requirements for gene activity in the segmentation of armadillo, fused, giant, and unpaired mutations in mosaic embryos

Roux's Arch. Dev. Biol.

Association of p60 src with Triton 100 resistant cellular structure correlates with morphological transformation

Article
Spatial expression of the Drosophila segment polarity gene armadillo is posttranscriptionally regulated by wingless