Induction of a sheet polymer of tubulin by Zn2+☆
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Cited by (142)
The effect of multivalent cations and Tau on paclitaxel-stabilized microtubule assembly, disassembly, and structure
2016, Advances in Colloid and Interface ScienceCitation Excerpt :In contrast, the efficiency of destabilizing cations (Zn2 +, Co2 +, Mn2 +, and Mg 2 +) increases systematically with increasing atomic number. It is interesting to note that under different preparation conditions, zinc ions may induce a novel sheet structure consisting of polymerized tubulin in the form of 2D sheets [50–53]. Aside from forming novel nanostructures these sheets have turned out to be crucial in electron crystallography studies to determine the structure of α/β tubulin fixed with paclitaxel.
Cryoelectron Microscopy Applications in the Study of Tubulin Structure, Microtubule Architecture, Dynamics and Assemblies, and Interaction of Microtubules with Motors
2010, Methods in EnzymologyCitation Excerpt :Shortly after the development of techniques for deriving 3D models from EM images of helical structures, the arrangement of the subunits was resolved in negative stain (Amos and Klug, 1974). Soon after, it was discovered that 2D crystals could be produced by polymerizing tubulin in the presence of zinc ions (Gaskin and Kress, 1977; Larsson et al., 1976), and the nascent technique of electron crystallography was soon applied to obtain a slightly higher resolution map of the structure (Baker and Amos, 1978; Crepeau et al., 1978). Further work on these crystals was limited by their small size and high disorder.
Macromolecular accessibility of fluorescent taxoids bound at a paclitaxel binding site in the microtubule surface
2005, Journal of Biological ChemistryDifferent activity of glyoxalase system enzymes in specimens of Sparus auratus exposed to sublethal copper concentrations
2003, Chemico-Biological InteractionsCitation Excerpt :These are toxic and reactive substances mainly rising from non-enzymatic and/or enzymatic degradation of dihydroxyacetone phosphate and glyceraldehyde-3-phosphate along the Embden-Meyerhof pathway [12]. Moreover, as observed in mammalian tissue extracts, bivalent ions as Cu++, Cd++ and Hg++ may interact with SH groups of tubulin [13,14], likely due to their high content of cysteine and methionine [15]. In addition, Cu affects cell energy production by decreasing the glycolytic rate [16–18].
Brain Microtubule Electrical Oscillations-Empirical Mode Decomposition Analysis
2023, Cellular and Molecular Neurobiology
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The present work was supported by grants from Statens Naturvetenskapliga Forskningsråd (No. 2535-0011).