Immunology
- NeoMUST: an accurate and efficient multi-task learning model for neoantigen presentation
NeoMUST, a multi-task learning model, efficiently predicts neoantigen presentation via MHC-I molecules, rivaling existing algorithms with significantly shorter training time. Its GitHub repository offers free access for advancing cancer immunotherapy development.
- Reduced myeloid commitment and increased uptake by macrophages of stem cell–derived HPS2 neutrophils
Our current work uses iPSC-derived neutrophils to unveil novel reasons for the neutropenia found in HPS2 patients. HPS2 iPSC-derived neutrophils have lower myeloid commitment, and are actively phagocytosed by macrophages present in the iPSC cultures or healthy donor macrophages.
- Nucleolar protein TAAP1/C22orf46 confers pro-survival signaling in non-small cell lung cancer
CRISPR/Cas9 screening identifies the gene C22orf46 to counteract pro-apoptotic signals provided by T cells or anti-neoplastic drugs and contributes to tumorigenesis.
- Variable PD-1 glycosylation modulates the activity of immune checkpoint inhibitors
Two anti-PD-1 antibodies bind to distinct glycoforms of PD-1 found on cells or in blood, highlighting the potential of target glycoprofiling in the development of differentiated therapeutics.
- 2′,3′ cyclic nucleotide 3′ phosphodiesterase 1 functional isoform antagonizes HIV-1 particle assembly
CNP1, not CNP2, is the primary isoform inhibiting HIV-1, highlighting posttranslational regulation in CNP antiviral role.
- A high-throughput two-cell assay for interrogating inhibitory signaling pathways in T cells
This work describes a high-throughput cellular assay specifically designed to study the understudied inhibitory signalling pathway in T cells.
- RNA helicase EIF4A1-mediated translation is essential for the GC response
Conditional mouse knock-out models show that EIF4A1, but not its cofactors EIF4B or EIF4H, is essential in B cells for their development, the GC response, and increased translation after activation.
- FAT10 is phosphorylated by IKKβ to inhibit the antiviral type-I interferon response
IKKβ-mediated phosphorylation of FAT10 dampens the antiviral type I interferon response by stabilizing OTUB1.
- Immunosuppressive low-density neutrophils in the blood of cancer patients display a mature phenotype
Low-density neutrophils (LDN) in cancer patient’s blood are heterogeneous: CD45high LDN are mature and suppress T-cell proliferation, whereas CD45low LDN are immature and non-suppressive.
- Synergistic roles of tristetraprolin family members in myeloid cells in the control of inflammation
Simultaneous deficiency of three tristetraprolin family members in myeloid cells resulted in severe inflammation in mice, suggesting that these three proteins act together to prevent inflammation.