Immunology
- Type I interferon regulates interleukin-1beta and IL-18 production and secretion in human macrophages
Interferon type I modulates the gene expression of inflammasome-related genes and reduces cytokine release induced by NLRP3 inflammasome activation in human macrophages in vitro.
- Novel chemotype NLRP3 inhibitors that target the CRID3-binding pocket with high potency
The NLRP3 inflammasome drives various diseases. Here, we describe novel potent and selective NLRP3-targeted inhibitors to bolster pharmacological studies and development of NLRP3-targeted therapies.
- CXCR4: from B-cell development to B cell–mediated diseases
This review provides an overview of the role of the C-X-C chemokine receptor type 4 (CXCR4) in B-cell development and in B cell–mediated disorders.
- Reverse-engineering the anti-MUC1 antibody 139H2 by mass spectrometry–based de novo sequencing
A widely used anti-MUC1 antibody (139H2) is sequenced by mass spectrometry, revealing the molecular basis of its glycosylation-independent binding to this tumor-associated antigen.
- SHIP1 deficiency causes inflammation-dependent retardation in skeletal growth
SHIP1 plays a cell-intrinsic role in osteoclast function and development, yet skeletal growth retardation in SHIP1-deficient mice is dependent on lymphocyte-induced inflammation.
- Breast implant surface topography triggers a chronic-like inflammatory response
This study explores the impact of breast implant surface topographies on immune responses, using analyses of periprosthetic fluids and in vitro cultures on model surface replicas, revealing that macrotextured implants significantly induce chronic-like inflammatory reactions.
- Oral bacteria induce IgA autoantibodies against a mesangial protein in IgA nephropathy model mice
This work shows that the CBX3, atypically expressed on the mesangial cell, is a target of IgA auto-Abs in IgA nephropathy model mice and patients. Such IgA auto-Abs are induced by oral bacteria in mice.
- Stability of gut microbiome after COVID-19 vaccination in healthy and immuno-compromised individuals
This study highlights the resilience of the gut microbiome to host immune changes triggered by COVID-19 vaccination and suggest minimal, if any, impact on microbiome-mediated processes.
- Targeting circulating labile heme as a defense strategy against malaria
Malaria remains a major cause of human morbidity and mortality. Circulating labile heme is an independent risk factor for severe P. falciparum malaria, suggesting that labile heme may be a therapeutic target against severe malaria.
- Zebrafish tsc1 and cxcl12a increase susceptibility to mycobacterial infection
Knockdown of miR-126 increases susceptibility to mycobacterial infection which can be independently reversed by targeting Tsc1/mTOR or ccr2 implicating macrophage function.