TY - JOUR T1 - Location-dependent maintenance of intrinsic susceptibility to mTORC1-driven tumorigenesis JF - Life Science Alliance JO - Life Sci. Alliance DO - 10.26508/lsa.201800218 VL - 2 IS - 2 SP - e201800218 AU - Gabrielle V Rushing AU - Asa A Brockman AU - Madelyn K Bollig AU - Nalin Leelatian AU - Bret C Mobley AU - Jonathan M Irish AU - Kevin C Ess AU - Cary Fu AU - Rebecca A Ihrie Y1 - 2019/04/01 UR - https://www.life-science-alliance.org/content/2/2/e201800218.abstract N2 - Neural stem/progenitor cells (NSPCs) of the ventricular–subventricular zone (V-SVZ) are candidate cells of origin for many brain tumors. However, whether NSPCs in different locations within the V-SVZ differ in susceptibility to tumorigenic mutations is unknown. Here, single-cell measurements of signal transduction intermediates in the mechanistic target of rapamycin complex 1 (mTORC1) pathway reveal that ventral NSPCs have higher levels of signaling than dorsal NSPCs. These features are linked with differences in mTORC1-driven disease severity: introduction of a pathognomonic Tsc2 mutation only results in formation of tumor-like masses from the ventral V-SVZ. We propose a direct link between location-dependent intrinsic growth properties imbued by mTORC1 and predisposition to tumor development. ER -