@article {Carissimoe201900298, author = {Guillaume Carissimo and Teck-Hui Teo and Yi-Hao Chan and Cheryl Yi-Pin Lee and Bernett Lee and Anthony Torres-Ruesta and Jeslin JL Tan and Tze-Kwang Chua and Siew-Wai Fong and Fok-Moon Lum and Lisa FP Ng}, title = {Viperin controls chikungunya virus{\textendash}specific pathogenic T cell IFNγ Th1 stimulation in mice}, volume = {2}, number = {1}, elocation-id = {e201900298}, year = {2019}, doi = {10.26508/lsa.201900298}, publisher = {Life Science Alliance}, abstract = {Chikungunya virus (CHIKV) has been a worldwide threat since its reemergence in La Reunion Island in 2004. Expression of the interferon-stimulated protein Viperin correlates with viral load burden in patients, and studies in mice have demonstrated its role to limit disease severity against CHIKV infection. Using Viperin-/- mice, we aimed to understand the contribution of Viperin to the T-cell immune response against CHIKV. CD4 T-cell depletion in Viperin-/- mice showed that increased late acute joint inflammation (5{\textendash}8 d postinfection) was exclusively mediated by T cells. Specifically, CHIKV-infected Viperin-/- mice showed an increased INFγ Th1 profile of CD4 T cells, enhanced INFγ stimulation by APCs, an increased INFγ secretion profile in the joint microenvironment, and increased numbers of inflammatory monocytes in virus-infected joints compared with WT mice. Bone marrow grafting experiments showed that Viperin expression in both hematopoietic and non-hematopoietic cells is instrumental in reducing disease severity associated with a CD4 T-cell response.}, URL = {https://www.life-science-alliance.org/content/2/1/e201900298}, eprint = {https://www.life-science-alliance.org/content/2/1/e201900298.full.pdf}, journal = {Life Science Alliance} }