Newest Articles
- Altered myocardial lipid regulation in junctophilin-2–associated familial cardiomyopathies
Our studies revealed, for the first time, unique alterations in the cardiac lipid composition—including distinct increases in neutral lipids and decreases in polar membrane lipids—in mice with HCM and DCM were caused by distinct JPH2 variants.
- A comparative study of structural variant calling in WGS from Alzheimer’s disease families
We developed a flexible protocol to generate a high-quality deletion call set and a truth set of Sanger sequencing–validated deletions with precise breakpoints between 1 and 17,000 bp from whole-genome sequencing data in multiplex families with Alzheimer’s disease.
- Lipotype acquisition during neural development is not recapitulated in stem cell–derived neurons
We report a time-resolved resource of lipid molecule abundance across brain development. Using the resource as a reference, we find that stem cell–derived neurons do not acquire a neural lipotype in vitro, unless supplemented with adequate metabolic precursors.
- Stable structures or PABP1 loading protects cellular and viral RNAs against ISG20-mediated decay
In this work, two novel elements that modulate the susceptibility of target RNAs to degradation by the antiviral RNase ISG20 are described.
- Metabolic and circadian inputs encode anticipatory biogenesis of hepatic fed microRNAs
Unravelling molecular and physiological mechanisms that couple circadian and metabolic cues to regulate anticipatory miR biogenesis during fed-fast-refed cycles in the liver.
- Galectin-8 modulates human osteoclast activity partly through isoform-specific interactions
Galectin-8 is emerging as a key player in osteoclastic bone resorption. Explore the specific functions of its isoforms through interactome analysis, revealing intricate mechanisms of bone biology.
- Cholesterol and COVID-19—therapeutic opportunities at the host/virus interface during cell entry
The key to cholesterol-related broad-spectrum antiviral strategies may be to disrupt cholesterol handling in specific cellular organelles.
- SHIP1 deficiency causes inflammation-dependent retardation in skeletal growth
SHIP1 plays a cell-intrinsic role in osteoclast function and development, yet skeletal growth retardation in SHIP1-deficient mice is dependent on lymphocyte-induced inflammation.
- Ageing-dependent thiol oxidation reveals early oxidation of proteins with core proteostasis functions
Proteome-wide analysis of thiol oxidation during chronological ageing of yeast reveals evolutionarily conserved proteins as early-oxidation targets with a potential impact on proteostasis regulation.
- Breast implant surface topography triggers a chronic-like inflammatory response
This study explores the impact of breast implant surface topographies on immune responses, using analyses of periprosthetic fluids and in vitro cultures on model surface replicas, revealing that macrotextured implants significantly induce chronic-like inflammatory reactions.