Newest Articles
- The RNA-binding protein Msi2 regulates autophagy during myogenic differentiation
This study identifies the RNA-binding protein Musashi2 as a novel regulator of myogenesis. Msi2 regulates myoblast differentiation via controlling autophagic protein LC3 expression. Loss of Msi2 results in defective skeletal muscle function in vivo.
- IFT88 maintains sensory function by localising signalling proteins along Drosophila cilia
DmIFT88 is dispensable to preserve the auditory ciliary structure but is critical to maintain sensory cilia function through binding and localisation of the ciliary proteins Iav and DmGucy2d.
- Oxidative phosphorylation is a pivotal therapeutic target of fibrodysplasia ossificans progressiva
Oxidative phosphorylation plays a pivotal role in heterotopic ossification associated with fibrodysplasia ossificans progressiva, underscoring its potential as a significant therapeutic target.
- Variety in the USP deubiquitinase catalytic mechanism
Quantitative analysis shows that USP family members have varying catalytic triads. Their third and fourth catalytic residues change in role and importance for nucleophilic attack and catalysis.
- Correction: Profiling subcellular localization of nuclear-encoded mitochondrial gene products in zebrafish
The vast majority (99%) of mitochondrial proteins are encoded by the nuclear genome, synthesized in the cytosol and imported into the organelle. Here we study the principles of mitochondrial import in vivo from the RNA perspective using zebrafish.
- Apical dehydration impairs the cystic fibrosis airway epithelium barrier via a β1-integrin/YAP1 pathway
Dehydration of the airway epithelial cell surface, a hallmark of CF, increases plasma membrane tension, resulting in altered Hippo signaling associated with the loss of barrier function.
- ADAM19 cleaves the PTH receptor and associates with brachydactyly type E
We studied a family with autosomal-dominant brachydactyly type E and found a mutated ADAM19; we show that ADAM19 cleaves PTHR1 and that aberrant PTHrP signaling could cause the phenotype.
- Inflammatory markers for improved recurrent UTI diagnosis in postmenopausal women
Here, we identify urinary cytokines that are differentially abundant in postmenopausal women with symptomatic recurrent UTI compared with controls and evaluate their ability to accurately diagnose UTI.
- Oral bacteria induce IgA autoantibodies against a mesangial protein in IgA nephropathy model mice
This work shows that the CBX3, atypically expressed on the mesangial cell, is a target of IgA auto-Abs in IgA nephropathy model mice and patients. Such IgA auto-Abs are induced by oral bacteria in mice.
- Epigenomic states contribute to coordinated allelic transcriptional bursting in iPSC reprogramming
Epigenomic states are linked to the coordinated allelic transcriptional bursting of genes involved in iPSC reprogramming.