Newest Articles
- Apical dehydration impairs the cystic fibrosis airway epithelium barrier via a β1-integrin/YAP1 pathway
Dehydration of the airway epithelial cell surface, a hallmark of CF, increases plasma membrane tension, resulting in altered Hippo signaling associated with the loss of barrier function.
- Oral bacteria induce IgA autoantibodies against a mesangial protein in IgA nephropathy model mice
This work shows that the CBX3, atypically expressed on the mesangial cell, is a target of IgA auto-Abs in IgA nephropathy model mice and patients. Such IgA auto-Abs are induced by oral bacteria in mice.
- ADAM19 cleaves the PTH receptor and associates with brachydactyly type E
We studied a family with autosomal-dominant brachydactyly type E and found a mutated ADAM19; we show that ADAM19 cleaves PTHR1 and that aberrant PTHrP signaling could cause the phenotype.
- Inflammatory markers for improved recurrent UTI diagnosis in postmenopausal women
Here, we identify urinary cytokines that are differentially abundant in postmenopausal women with symptomatic recurrent UTI compared with controls and evaluate their ability to accurately diagnose UTI.
- Epigenomic states contribute to coordinated allelic transcriptional bursting in iPSC reprogramming
Epigenomic states are linked to the coordinated allelic transcriptional bursting of genes involved in iPSC reprogramming.
- Knockout of PA200 improves proteasomal degradation and myelination in a proteotoxic neuropathy
Proteasome Activator 200 is upregulated in a neuropathy model in which protein degradation by the proteasome is impaired. Knocking out PA200 unexpectedly rescued proteostasis and prevented neuropathy.
- Stability of gut microbiome after COVID-19 vaccination in healthy and immuno-compromised individuals
This study highlights the resilience of the gut microbiome to host immune changes triggered by COVID-19 vaccination and suggest minimal, if any, impact on microbiome-mediated processes.
- Genome-wide CRISPR screen reveals the synthetic lethality between BCL2L1 inhibition and radiotherapy
Unbiased whole-genome CRISPR/Cas9 screening reveals that loss of BCL2L1 shows synthetic lethality with radiation, which is further confirmed with the use of BCL2L1 inhibitor. Thus, radiation plus inhibitors targeting BCL2 family proteins is a promising combination therapy for cancers.
- Targeting circulating labile heme as a defense strategy against malaria
Malaria remains a major cause of human morbidity and mortality. Circulating labile heme is an independent risk factor for severe P. falciparum malaria, suggesting that labile heme may be a therapeutic target against severe malaria.
- Zebrafish tsc1 and cxcl12a increase susceptibility to mycobacterial infection
Knockdown of miR-126 increases susceptibility to mycobacterial infection which can be independently reversed by targeting Tsc1/mTOR or ccr2 implicating macrophage function.