Newest Articles
- pADP-ribosylation regulates the cytoplasmic localization, cleavage, and pro-apoptotic function of HuR
Our current work demonstrates that the non-covalent PARylation of HuR plays a key role in regulating its pro-apoptotic function by preventing its cytoplasmic localization and cleavage.
- Linc00673-V3 positively regulates autophagy by promoting Smad3-mediated LC3B transcription in NSCLC
Linc00673-V3 isoform protects Smad3 from STUB1-mediated degradation and accumulated Smad3 facilitates LC3B transcription which ultimately promotes autophagy and chemoresistance in NSCLC.
- Type I interferon regulates interleukin-1beta and IL-18 production and secretion in human macrophages
Interferon type I modulates the gene expression of inflammasome-related genes and reduces cytokine release induced by NLRP3 inflammasome activation in human macrophages in vitro.
- Novel chemotype NLRP3 inhibitors that target the CRID3-binding pocket with high potency
The NLRP3 inflammasome drives various diseases. Here, we describe novel potent and selective NLRP3-targeted inhibitors to bolster pharmacological studies and development of NLRP3-targeted therapies.
- CXCR4: from B-cell development to B cell–mediated diseases
This review provides an overview of the role of the C-X-C chemokine receptor type 4 (CXCR4) in B-cell development and in B cell–mediated disorders.
- Immunogenicity and effectiveness of an mRNA therapeutic vaccine for HPV-related malignancies
mHTV-02 functions as a candidate effective therapeutic mRNA-LNP vaccine via intramuscular or intratumoral administration routes for treating malignancies caused by HPV16 or HPV18 infections.
- The Rtf1/Prf1-dependent histone modification axis counteracts multi-drug resistance in fission yeast
Mutations in a conserved histone modification axis confer a unique drug-tolerant phenotype in fission yeast, and suggest a mode of gene regulation shared with the Rpb1 C-terminal domain.
- Genetic structure and diversity of the rfb locus of pathogenic species of the genus Leptospira
This study provides a broad investigation of the gene composition of the rfb locus, the main genetic factor associated with serology in Leptospira, and opens the way for molecular diagnostics in leptospirosis.
- Reverse-engineering the anti-MUC1 antibody 139H2 by mass spectrometry–based de novo sequencing
A widely used anti-MUC1 antibody (139H2) is sequenced by mass spectrometry, revealing the molecular basis of its glycosylation-independent binding to this tumor-associated antigen.
- Aberrant DNA methylation distorts developmental trajectories in atypical teratoid/rhabdoid tumors
This study describes how aberrant DNA methylation–driven epigenetic regulation affects DNA binding of key transcriptions and maintains the malignant, low differentiation cell state in AT/RTs.