Cell Biology
- Decline of DNA damage response along with myogenic differentiation
In postmitotic myotubes, DNA repair processes such as Base Excision Repair, and Non-Homologous End Joining are weakened compared with the proliferative precursors myoblasts.
- Enhancer-driven 3D chromatin domain folding modulates transcription in human mammary tumor cells
The study shows that estrogen activates transcription within pre-established chromosomal 3D architectures, strengthening enhancer interactions through local accumulation of the estrogen receptor α.
- Mitochondrial phosphoproteomes are functionally specialized across tissues
This study explores tissue-specific mitochondrial proteomes and phosphoproteomes in unprecedented depth, offering valuable insights into mitochondrial organization and specialization.
- DOCK1 insufficiency disrupts trophoblast function and pregnancy outcomes via DUSP4-ERK pathway
This study reveals that decreased DOCK1 in placental villi affects trophoblast function via the DUSP4-ERK pathway, providing insights into adverse pregnancy outcomes.
- Mechanisms of cellular crosstalk in the gastric tumor microenvironment are mediated by YAP1 and STAT3
The study shows that Yap1 expression correlates with poor outcomes in human gastric cancer and causally contributes to disease progression in mice via cancer cell–intrinsic and –extrinsic mechanisms.
- Cristae dynamics is modulated in bioenergetically compromised mitochondria
Live-cell super-resolution nanoscopy reveals modulation of cristae dynamics in bioenergetically compromised mitochondria demonstrating that cristae morphology and dynamics are intricately connected.
- DCAF14 regulates CDT2 to promote SET8-dependent replication fork protection
DCAF14 modulates CRL4CDT2-dependent turnover during DNA replication. Loss of DCAF14 causes nascent strand degradation due to excessive proteasomal turnover of SET8 by aberrant CDT2 activity.
- FAT10 is phosphorylated by IKKβ to inhibit the antiviral type-I interferon response
IKKβ-mediated phosphorylation of FAT10 dampens the antiviral type I interferon response by stabilizing OTUB1.
- ESYT1 tethers the ER to mitochondria and is required for mitochondrial lipid and calcium homeostasis
A protein complex composed of the outer mitochondrial membrane protein SYNJ2BP and the endoplasmic reticulum protein ESYT1 tethers the two organelles to facilitate calcium and lipid transfer.
- Enucleation of the C. elegans embryo revealed dynein-dependent spacing between microtubule asters
Using a genetic trick to produce enucleated C. elegans embryos, the authors revealed how the microtubule asters take space between each other inside the cell.