Cancer
- Loss-of-function cancer-linked mutations in the EIF4G2 non-canonical translation initiation factor
This work identifies missense mutations in the translation initiation factor EIF4G2 gene in cancer, showing loss-of-function effects on binding to interacting proteins and translational activity.
- Correction: LACTB exerts tumor suppressor properties in epithelial ovarian cancer through regulation of Slug
We show the ability of LACTB to function as a tumor suppressor in ovarian cancer through down-regulation of Slug and induction of differentiation.
- Proteomic-based stratification of intermediate-risk prostate cancer patients
This study demonstrates the ability of a protein-based signature to risk-stratify prostate cancer patients with Gleason grade groups 2 and 3 and predict the risk of biochemical recurrence.
- Analysis of the indispensable RAD51 cofactor BRCA2 in Naganishia liquefaciens, a Basidiomycota yeast
Identification of the BRCA2 homolog in the Basidiomycota yeast Naganishia liquefaciens reveals the general attributes of fungal BRCA2 and its essential role in Rad51-mediated homologous recombination.
- Intrinsic deletion at 10q23.31, including the PTEN gene locus, is aggravated upon CRISPR-Cas9–mediated genome engineering in HAP1 cells mimicking cancer profiles
The unintended 10q23.31 deletion frequency rises in HAP1 cells stressed during CRISPR-Cas9 engineering, leading to aberrant molecular and cellular changes resembling common cancer patient deletions.
- Patient-specific analysis of co-expression to measure biological network rewiring in individuals
Cosinet has the potential to empower personalized treatment by accurately quantifying the degree of rewiring in individual samples compared with reference conditions using mechanism-related differential co-expression sub-networks.
- DCAF14 regulates CDT2 to promote SET8-dependent replication fork protection
DCAF14 modulates CRL4CDT2-dependent turnover during DNA replication. Loss of DCAF14 causes nascent strand degradation due to excessive proteasomal turnover of SET8 by aberrant CDT2 activity.
- Spt5 interacts genetically with Myc and is limiting for brain tumor growth in Drosophila
Knockdown of Spt5 in Drosophila affects various Myc-dependent phenotypes and delays the growth of a Myc-dependent brain tumor, thereby significantly extending the longevity of tumorous animals.
- Integrins regulate hERG1 dynamics by girdin-dependent Gαi3: signaling and modeling in cancer cells
We combine experimental data and mathematical modeling to offer a coherent explanation of the dynamics of hERG1 interaction with integrins, which governs f-actin organization and migration in cancer cells.
- Exploring the basis of heterogeneity of cancer aggressiveness among the mutated POLE variants
Mechanisms and consequences of POLE mutations in human cancers.