Cancer
- pADP-ribosylation regulates the cytoplasmic localization, cleavage, and pro-apoptotic function of HuR
Our current work demonstrates that the non-covalent PARylation of HuR plays a key role in regulating its pro-apoptotic function by preventing its cytoplasmic localization and cleavage.
- Linc00673-V3 positively regulates autophagy by promoting Smad3-mediated LC3B transcription in NSCLC
Linc00673-V3 isoform protects Smad3 from STUB1-mediated degradation and accumulated Smad3 facilitates LC3B transcription which ultimately promotes autophagy and chemoresistance in NSCLC.
- Aberrant DNA methylation distorts developmental trajectories in atypical teratoid/rhabdoid tumors
This study describes how aberrant DNA methylation–driven epigenetic regulation affects DNA binding of key transcriptions and maintains the malignant, low differentiation cell state in AT/RTs.
- C5aR plus MEK inhibition durably targets the tumor milieu and reveals tumor cell phagocytosis
C5aR antagonist and MEK inhibition combination therapy changes the tumor microenvironment and induces ongoing tumor cell phagocytosis.
- Oncogenic mutations of KRAS modulate its turnover by the CUL3/LZTR1 E3 ligase complex
The study reveals how KRAS mutations disrupt LZTR1-mediated KRAS degradation, shedding light on potential mechanisms in oncogenesis.
- Genome-wide CRISPR screen reveals the synthetic lethality between BCL2L1 inhibition and radiotherapy
Unbiased whole-genome CRISPR/Cas9 screening reveals that loss of BCL2L1 shows synthetic lethality with radiation, which is further confirmed with the use of BCL2L1 inhibitor. Thus, radiation plus inhibitors targeting BCL2 family proteins is a promising combination therapy for cancers.
- NeoMUST: an accurate and efficient multi-task learning model for neoantigen presentation
NeoMUST, a multi-task learning model, efficiently predicts neoantigen presentation via MHC-I molecules, rivaling existing algorithms with significantly shorter training time. Its GitHub repository offers free access for advancing cancer immunotherapy development.
- Nucleolar protein TAAP1/C22orf46 confers pro-survival signaling in non-small cell lung cancer
CRISPR/Cas9 screening identifies the gene C22orf46 to counteract pro-apoptotic signals provided by T cells or anti-neoplastic drugs and contributes to tumorigenesis.
- VE-cadherin junction dynamics in initial lymphatic vessels promotes lymph node metastasis
Exposure of initial dermal lymphatics to VEGFA or a tumor results in zippering of VE-cadherin at junctions, concomitant with Src-dependent VE-cadherin fragmentation.
- Loss-of-function cancer-linked mutations in the EIF4G2 non-canonical translation initiation factor
This work identifies missense mutations in the translation initiation factor EIF4G2 gene in cancer, showing loss-of-function effects on binding to interacting proteins and translational activity.