Most read article(s)
- CRL4DCAF1 ubiquitin ligase regulates PLK4 protein levels to prevent premature centriole duplication
This study identifies the E3 ubiquitin ligase, CRL4DCAF1, as a new regulator of polo-like kinase 4, PLK4, protein levels in the G2 phase of the cell cycle to prevent premature duplication of centrioles.
- Phosphorylation of Rec8 cohesin complexes regulates mono-orientation of kinetochores in meiosis I
Phosphorylation of the Rec8 cohesin complexes plays a crucial role in establishing mono-orientation of sister kinetochores which is important for reductional division in meiosis I in fission yeast.
- Aberrant DNA methylation distorts developmental trajectories in atypical teratoid/rhabdoid tumors
This study describes how aberrant DNA methylation–driven epigenetic regulation affects DNA binding of key transcriptions and maintains the malignant, low differentiation cell state in AT/RTs.
- Generation of marmoset primordial germ cell–like cells under chemically defined conditions
Marmoset primordial germ cells (PGCs) express SOX17, AP2Ɣ, and BLIMP1 in vivo, and under specific feeder-free conditions, marmoset iPSCs can be induced into PGC-like cells in vitro.
- Fibro-adipogenic progenitors of dystrophic mice are insensitive to NOTCH regulation of adipogenesis
The NOTCH pathway, in concert with TNFa, restrains adipogenesis of muscle fibro-adipogenic progenitors (FAPs). Dystrophin-deficient FAPs are less sensitive to NOTCH anti-adipogenic signals, thus explaining why fat infiltrations are solely observed in the muscles of dystrophic individuals.
- Novel chemotype NLRP3 inhibitors that target the CRID3-binding pocket with high potency
The NLRP3 inflammasome drives various diseases. Here, we describe novel potent and selective NLRP3-targeted inhibitors to bolster pharmacological studies and development of NLRP3-targeted therapies.
- Altered myocardial lipid regulation in junctophilin-2–associated familial cardiomyopathies
Our studies revealed, for the first time, unique alterations in the cardiac lipid composition—including distinct increases in neutral lipids and decreases in polar membrane lipids—in mice with HCM and DCM were caused by distinct JPH2 variants.
- A comparative study of structural variant calling in WGS from Alzheimer’s disease families
We developed a flexible protocol to generate a high-quality deletion call set and a truth set of Sanger sequencing–validated deletions with precise breakpoints between 1 and 17,000 bp from whole-genome sequencing data in multiplex families with Alzheimer’s disease.
- C5aR plus MEK inhibition durably targets the tumor milieu and reveals tumor cell phagocytosis
C5aR antagonist and MEK inhibition combination therapy changes the tumor microenvironment and induces ongoing tumor cell phagocytosis.
- Vnn1 pantetheinase limits the Warburg effect and sarcoma growth by rescuing mitochondrial activity
Expression of the Vnn1 pantetheinase by sarcomas is tumor suppressive by limiting the use of aerobic glycolysis for growth and rescuing mitochondrial activity through CoA regeneration.