Most read article(s)
- Inhibition of a transcriptional repressor rescues hearing in a splicing factor–deficient mouse
The vital role of the splicing factor SRRM4 in vestibular and inner hair cells of the ear is inactivation of the gene repressor REST; however, in outer hair cells, SRRM4 is dispensable for REST inactivation, which SRRM3 accomplishes independently.
- Starvation-resistant cavefish reveal conserved mechanisms of starvation-induced hepatic lipotoxicity
Cavefish evolved protection from starvation-induced liver damage through a reduction in fatty acid uptake regulated by FATP2, a mechanism conserved through 400 million years of animal evolution.
- An immune-based tool platform for in vivo cell clearance
A tool platform that allows the exploration of immune-mediated cytotoxic therapies to target pathological cells in diseases beyond cancer.
- Systemic metabolic depletion of gut microbiome undermines responsiveness to melanoma immunotherapy
Relationship between gut microbiome composition and immunotherapy efficacy.
- Location-dependent maintenance of intrinsic susceptibility to mTORC1-driven tumorigenesis
Per-cell quantification of mTORC1 signaling activity in neural stem/progenitor cells reveals differential signaling, proliferative, and tumor-forming capability between dorsal and ventral cells within a single niche.
- Oncogenic mutations of KRAS modulate its turnover by the CUL3/LZTR1 E3 ligase complex
The study reveals how KRAS mutations disrupt LZTR1-mediated KRAS degradation, shedding light on potential mechanisms in oncogenesis.
- A genetic screen to uncover mechanisms underlying lipid transfer protein function at membrane contact sites
A genetic screen in Drosophila photoreceptors uncovers multiple regulators of lipid transfer function and endoplasmic reticulum–plasma membrane contact sites.
- Tight regulation of a nuclear HAPSTR1-HUWE1 pathway essential for mammalian life
The recently discovered HAPSTR1 protein facilitates a nuclear quality control pathway essential for mammalian life.
- Proteomics characterisation of the L929 cell supernatant and its role in BMDM differentiation
L929 cell supernatant is commonly used to differentiate murine macrophages from bone marrow. The supernatant and its effect on macrophage phenotype was characterised by proteomics and the authors identified novel immunoregulatory proteins.
- Genetic ablation of Immt induces a lethal disruption of the MICOS complex
A new conditional mouse model deleting Immt/MIC60 reveals the necessity of this protein in vivo and provides an important resource for future research into the mitochondrial MICOS complex.